Disease history and medication use as risk factors for the clinical manifestation of type 1 diabetes in children and young adults: an explorative case control study.
Disease history and medication use as risk factors for the clinical manifestation of type 1 diabetes in children and young adults: an explorative case control study.
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BACKGROUND: There is a highly variable asymptomatic period of beta cell destruction prior to the clinical presentation of type1 diabetes.It is not well known what triggers type 1 diabetes to Setting Sprays become a clinically overt disease.This explorative study aimed to identify the association between disease history/medication use and the clinical manifestation of type 1 diabetes.METHODOLOGY/PRINCIPAL FINDINGS: An explorative case control study was conducted in the Dutch PHARMO Record Linkage System.Cases (n = 1,107) were younger than 25 years and had at least 2 insulin prescriptions between 1999 and 2009.
For each case, up to 4 controls (without any prescription for the glucose lowering medications (n = 4,424)) were matched by age and sex.Conditional logistic regression analysis was used to evaluate the association between disease history/medication use in the year prior to the diagnosis of type 1 diabetes and clinical manifestation of this disease.Type1 diabetes was significantly associated with a history of mental disorder (odds ratio (OR) 8.0, 95% confidence interval (CI) 1.5-43.
7), anemia (OR 5.1, 95% CI 1.1-22.9), and disease of digestive system (OR 2.6, 95% CI 1.
2-5.5).The following drug exposures were significantly associated with the clinical manifestation of type 1 diabetes: "systemic hormonal preparations" (OR 1.7, 95% CI 1.1-2.
6), medications for "blood and blood forming organs" (OR 1.6, 95% CI 1.1-2.6), "alimentary tract and metabolism" (OR 1.3, 95% CI 1.
1-1.6), and "anti-infectives for systemic use" (OR 1.2, 95% CI 1.01-1.4).
CONCLUSIONS: Our explorative study demonstrated that in the year prior to the presentation of type 1 diabetes in children High Chair and young adults, hospitalization for a diverse group of diseases and drug exposures were significantly more prevalent compared with age- and sex-matched diabetes-free controls.